The model for end-stage liver disease score is useful for predicting economic outcomes in adult cases of living donor liver transplantation

Takayuki Kogure, Yoshiyuki Ueno, Naoki Kawagishi, Noriatsu Kanno, Yoko Yamagiwa, Koji Fukushima, Susumu Satomi, Tooru Shimosegawa

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22 Citations (Scopus)

Abstract

Background: The model for end-stage liver disease (MELD) is useful for assessing the recipients of liver transplants, namely, deceased-donor transplantation. The application of MELD for living donor liver transplantation (LDLT) is under investigation. Thus, the aim of this study was to analyze the impact of the MELD score in LDLT in Japan. Methods: Seventeen adult cases of LDLT during 2001 to 2005 were enrolled. Indications for LDLT were primary biliary cirrhosis, seven; liver cirrhosis, two; hepatocellular carcinoma (HCC), three; metabolic liver disease, one; primary sclerosing cholangitis, two; Caroli's disease, one; and biliary atresia, one. Total medical charges during the operative periods were retrospectively evaluated. The united network of organ sharing (UNOS) modified was obtained using preoperative clinical data. Results: The average medical expense of the 17 cases was approximately $97901. The UNOS-modified MELD score was 22.1. A statistically significant positive correlation was found between the MELD score and medical expense (P = 0.0086, p = 0.657), and between the MELD score and the length of stay in the intensive care unit (ICU) (P = 0.0396, p = 0.515). The cause of the liver disease leading to transplantation was not related to MELD score, medical expense, or length of ICU stay. Conclusions: Although not originally designed for the application to LDLT, the MELD score is useful for predicting medical expenses in LDLT. Similar to those of deceased-donor liver transplantation, the disadvantage of high medical expenses associated with a high MELD score allow consideration of an earlier elective operation in suitable cases.

Original languageEnglish
Pages (from-to)1005-1010
Number of pages6
JournalJournal of gastroenterology
Volume41
Issue number10
DOIs
Publication statusPublished - 2006 Oct

Keywords

  • Living donor liver transplantation
  • MELD score
  • Milan criteria

ASJC Scopus subject areas

  • Gastroenterology

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    Kogure, T., Ueno, Y., Kawagishi, N., Kanno, N., Yamagiwa, Y., Fukushima, K., Satomi, S., & Shimosegawa, T. (2006). The model for end-stage liver disease score is useful for predicting economic outcomes in adult cases of living donor liver transplantation. Journal of gastroenterology, 41(10), 1005-1010. https://doi.org/10.1007/s00535-006-1887-x