The methylation status of FBXW7 β-form correlates with histological subtype in human thymoma

Zhaodi Gu, Hidetoshi Mitsui, Kenichi Inomata, Masako Honda, Chiaki Endo, Akira Sakurada, Masami Sato, Yoshinori Okada, Takashi Kondo, Akira Horii

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

FBXW7 is reported to be a tumor suppressor gene, and the functional inactivation of FBXW7 has been reported in various human tumors. In this study, we investigated the FBXW7 gene in human thymoma; although no mutations were evident, a significantly high frequency of methylation in the FBXW7 β-form promoter was observed in types B1 or higher (P = 0.014). We propose a novel mechanism for the pathogenesis of thymoma by FBXW7 β-form and hypothesize that expressional suppression plays an important role in the malignant potential of thymoma.

Original languageEnglish
Pages (from-to)685-688
Number of pages4
JournalBiochemical and biophysical research communications
Volume377
Issue number2
DOIs
Publication statusPublished - 2008 Dec 12

Keywords

  • FBXW7 β-form
  • Methylation
  • Thymoma

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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