@article{85b572d1f4624a8e89433bb839e9f1f7,
title = "The methylation status of FBXW7 β-form correlates with histological subtype in human thymoma",
abstract = "FBXW7 is reported to be a tumor suppressor gene, and the functional inactivation of FBXW7 has been reported in various human tumors. In this study, we investigated the FBXW7 gene in human thymoma; although no mutations were evident, a significantly high frequency of methylation in the FBXW7 β-form promoter was observed in types B1 or higher (P = 0.014). We propose a novel mechanism for the pathogenesis of thymoma by FBXW7 β-form and hypothesize that expressional suppression plays an important role in the malignant potential of thymoma.",
keywords = "FBXW7 β-form, Methylation, Thymoma",
author = "Zhaodi Gu and Hidetoshi Mitsui and Kenichi Inomata and Masako Honda and Chiaki Endo and Akira Sakurada and Masami Sato and Yoshinori Okada and Takashi Kondo and Akira Horii",
note = "Funding Information: We are grateful to Dr. Barbara Lee Smith Pierce (University of Maryland University College) for editorial work in the preparation of this manuscript. This work was supported in part by Grants-in-Aid, the 21st Century COE Program Special Research Grant, and Academic Frontier Project for Private Universities: matching fund subsidy 2006–2010 from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and by a Grant-in-Aid for Cancer Research from the Ministry of Health, Labour and Welfare of Japan.",
year = "2008",
month = dec,
day = "12",
doi = "10.1016/j.bbrc.2008.10.047",
language = "English",
volume = "377",
pages = "685--688",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "2",
}