TY - JOUR
T1 - The metabolic conversion of 9,11,13-eleostearic acid (18:3) to 9,11-conjugated linoleic acid (18:2) in the rat
AU - Tsuzuki, Tsuyoshi
AU - Igarashi, Miki
AU - Komai, Michio
AU - Miyazawa, Teruo
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2003/6
Y1 - 2003/6
N2 - The presence of a significant amount of 9,11-conjugated linoleic acid (CLA, 9,11-18:2) was confirmed in the liver and plasma lipids of rats fed a 1% (w/w % of diet) eleostearic acid (ESA, 9,11,13-18:3) diet for 4 wk. The chemical structure of the 9,11-CLA apparent in the tissue lipids was identified by gas chromatography-electron impact mass spectrometry after its conversion to a 4,4-dimethyloxazoline derivative. The concentration of CLA in the total fatty acids of the liver and plasma lipids reached to about 1% for each in the CLA-supplemented rats, while reaching 3,2% and 2.5%, respectively, in the ESA-supplemented rats. The results suggest that α-ESA is metabolized partially to CLA via a delta 13-saturation reaction in the rat. Some biological activities observed in α-ESA-fed animals may be ascribed also to CLA that is formed from ESA in the body.
AB - The presence of a significant amount of 9,11-conjugated linoleic acid (CLA, 9,11-18:2) was confirmed in the liver and plasma lipids of rats fed a 1% (w/w % of diet) eleostearic acid (ESA, 9,11,13-18:3) diet for 4 wk. The chemical structure of the 9,11-CLA apparent in the tissue lipids was identified by gas chromatography-electron impact mass spectrometry after its conversion to a 4,4-dimethyloxazoline derivative. The concentration of CLA in the total fatty acids of the liver and plasma lipids reached to about 1% for each in the CLA-supplemented rats, while reaching 3,2% and 2.5%, respectively, in the ESA-supplemented rats. The results suggest that α-ESA is metabolized partially to CLA via a delta 13-saturation reaction in the rat. Some biological activities observed in α-ESA-fed animals may be ascribed also to CLA that is formed from ESA in the body.
KW - Conjugated fatty acid
KW - Conjugated linoleic acid
KW - Conjugated trienoic acid
KW - Eleostearic acid
KW - Tung oil
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U2 - 10.3177/jnsv.49.195
DO - 10.3177/jnsv.49.195
M3 - Article
C2 - 12953798
AN - SCOPUS:0041811623
VL - 49
SP - 195
EP - 200
JO - The Journal of vitaminology
JF - The Journal of vitaminology
SN - 0301-4800
IS - 3
ER -