The metabolic conversion of 9,11,13-eleostearic acid (18:3) to 9,11-conjugated linoleic acid (18:2) in the rat

Tsuyoshi Tsuzuki, Miki Igarashi, Michio Komai, Teruo Miyazawa

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The presence of a significant amount of 9,11-conjugated linoleic acid (CLA, 9,11-18:2) was confirmed in the liver and plasma lipids of rats fed a 1% (w/w % of diet) eleostearic acid (ESA, 9,11,13-18:3) diet for 4 wk. The chemical structure of the 9,11-CLA apparent in the tissue lipids was identified by gas chromatography-electron impact mass spectrometry after its conversion to a 4,4-dimethyloxazoline derivative. The concentration of CLA in the total fatty acids of the liver and plasma lipids reached to about 1% for each in the CLA-supplemented rats, while reaching 3,2% and 2.5%, respectively, in the ESA-supplemented rats. The results suggest that α-ESA is metabolized partially to CLA via a delta 13-saturation reaction in the rat. Some biological activities observed in α-ESA-fed animals may be ascribed also to CLA that is formed from ESA in the body.

Original languageEnglish
Pages (from-to)195-200
Number of pages6
JournalJournal of nutritional science and vitaminology
Volume49
Issue number3
DOIs
Publication statusPublished - 2003 Jun

Keywords

  • Conjugated fatty acid
  • Conjugated linoleic acid
  • Conjugated trienoic acid
  • Eleostearic acid
  • Tung oil

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Fingerprint Dive into the research topics of 'The metabolic conversion of 9,11,13-eleostearic acid (18:3) to 9,11-conjugated linoleic acid (18:2) in the rat'. Together they form a unique fingerprint.

  • Cite this