The maximum tumour length in biopsy cores as a predictor of outcome after radical prostatectomy

Norihiro Hayashi, Mitsuyoshi Urashima, Hidetoshi Kuruma, Yoichi Arai, Sadahito Kuwao, Masatsugu Iwamura, Shin Egawa

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Study Type - Diagnostic (non-consecutive study) Level of Evidence 3b OBJECTIVES: To evaluate maximum tumour length (MTL) in biopsy cores as a predictor of prostate-specific antigen (PSA)-failure, systemic failure, and death from prostate cancer after radical prostatectomy (RP). PATIENTS AND METHODS: We assessed 209 men with clinically localized prostate cancer treated with RP; preoperative variables were correlated with unfavourable pathological characteristics in the RP specimens and with outcome after surgery, using univariate and multivariate analysis. RESULTS: The median (range) MTL was 4 (0.2-19) mm and correlated with adverse pathological findings, including specimen Gleason score (P = 0.003), pT3 (P < 0.001), seminal vesicle invasion (P < 0.001) and lymph node involvement (P = 0.019) in multivariate analysis. Preoperative PSA (P < 0.001), biopsy Gleason score (P = 0.002), and MTL (P = 0.045) were independent predictors of PSA failure, whereas only MTL remained a predictor of systemic-failure (P < 0.001) and death from prostate cancer (P = 0.004). The median (range) follow-up after surgery was 90 (17-152) months, during which 83 patients had PSA failure, 20 developed systemic failure and 15 died from prostate cancer. CONCLUSIONS: The MTL correlates well with adverse pathological findings and appears to be an independent predictor of outcome after RP. Patients with a greater MTL might have cancer with an aggressive phenotype and therefore be candidates for more aggressive therapies.

Original languageEnglish
Pages (from-to)175-180
Number of pages6
JournalBJU International
Volume101
Issue number2
DOIs
Publication statusPublished - 2008 Jan

Keywords

  • Biopsy
  • Maximum tumour length
  • Prognosis
  • Prostate cancer

ASJC Scopus subject areas

  • Urology

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