The mammalian homolog of the Drosophila discs large tumor suppressor protein up-regulates expression of the ELR+ CXC chemokine Scyb5

Tomoiki Aiba, Kazuyoshi Kohu, Takefumi Ishidao, Naomi Yasui, Akira Horii, Hiroyuki Aburatani, Tetsu Akiyama

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The mammalian homolog of the Drosophila discs large tumor suppressor protein Dlg functions as a scaffolding protein that facilitates the transmission of diverse signals. In the present study, we attempted to identify the downstream target genes of Dlg, and found that Dlg up-regulates expression of the ELR+ CXC chemokine Scyb5, which has been implicated in the immune system. Our finding suggests that Scyb5 may play an important role in the tumor suppressor function of Dlg.

Original languageEnglish
Pages (from-to)191-194
Number of pages4
JournalBiochemical and biophysical research communications
Volume337
Issue number1
DOIs
Publication statusPublished - 2005 Nov 11

Keywords

  • Discs large
  • Dlg
  • MAGUK
  • Microarray
  • Scaffolding protein
  • Scyb5
  • Tumor suppressor

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'The mammalian homolog of the Drosophila discs large tumor suppressor protein up-regulates expression of the ELR<sup>+</sup> CXC chemokine Scyb5'. Together they form a unique fingerprint.

Cite this