The magnitude and duration of cyclic stretch affect JNK and p38 activation in MC3T3-E1 pre-osteoblastic cells

Hiroyuki Matsui, Naoto Fukuno, Keiichi Sasaki, Osamu Suzuki, Takayasu Kobayashi, Shinri Tamura

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Although mechanical stress has been shown to regulate bone modeling and remodeling, the mechanisms of bone remodeling after mechanical stress loading are not fully understood. In this study we determined the effects of cyclic mechanical stretch of varying magnitudes and durations on the activation of JNK and p38 in MC3T3-E1 cells. Phosphorylation of both JNK and p38 was observed 5 min after the onset of stretch-load and increased proportionally with elongation. However, a marked increase in the phosphorylation of p38 but not JNK was observed when cells were stretched to 4% elongation. These observations raise the possibility that JNK and p38 play different roles in bone remodeling depending on the magnitude and duration of mechanical stretch.

Original languageEnglish
Title of host publication2007 International Symposium on Micro-NanoMechatronics and Human Science, MHS
Pages183-186
Number of pages4
DOIs
Publication statusPublished - 2007 Dec 1
Event2007 International Symposium on Micro-NanoMechatronics and Human Science, MHS - Nagoya, Japan
Duration: 2007 Nov 112007 Nov 14

Publication series

Name2007 International Symposium on Micro-NanoMechatronics and Human Science, MHS

Other

Other2007 International Symposium on Micro-NanoMechatronics and Human Science, MHS
CountryJapan
CityNagoya
Period07/11/1107/11/14

ASJC Scopus subject areas

  • Artificial Intelligence
  • Computer Networks and Communications
  • Human-Computer Interaction
  • Electrical and Electronic Engineering

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