The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation

Masahiro Okada, Atsushi Matsuzawa, Akihiko Yoshimura, Hidenori Ichijo

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Results: Inhibition of CaMKII, TAK1, or JNK specifically suppressed lysosome rupture-induced NLRP3 inflammasome activation.

Background: The mechanisms underlying lysosome rupture-mediated inflammasome activation are not understood.

Conclusion: Activation of the Ca2+-CaMKII-TAK1-JNK pathway in lysosome rupture is necessary for complete activation of the NLRP3 inflammasome.

Significance: Our results suggest novel roles for the Ca2+-CaMKII-TAK1-JNK pathway in the regulation of the inflammasome and propose potential therapeutic targets for inflammatory diseases.

Original languageEnglish
Pages (from-to)32926-32936
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number47
DOIs
Publication statusPublished - 2014 Nov 21

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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