The lower safety level of blood pressure evaluated by 123I-IMP single-photon emission computed tomography in acute cerebral infarction patients

Taizen Nakase, Shotaroh Yoshioka, Masahiro Sasaki, Akifumi Suzuki

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: At the acute phase of cerebral infarction, the autoregulation of cerebral blood flow (CBF) is compromised. In this study, we explored the lower safety level of blood pressure (BP) for maintaining optimal CBF in acute cerebral infarction patients. Patients & methods: Acute middle cerebral artery territorial infarctions were screened. Patients who had single-photon emission computed tomography performed within 7 days following onset were enrolled (n = 30). The CBF ratio (ischemic:intact) was calculated at the border zone of the middle cerebral artery. Vascular lesions were assessed by magnetic resonance angiography. Results: The lowest BP level that maintained the CBF ratio ≥0.6 was 109 mmHg in patients with mild-to-moderate stenosis and 142/79 mmHg in patients with occlusion at the lesion side and stenosis at the intact side by the linear regression analysis. Conclusion: BP control should be carefully managed in acute stroke patients with occlusion and stenosis in the main arteries of the brain.

Original languageEnglish
Pages (from-to)535-543
Number of pages9
JournalClinical Practice
Volume10
Issue number4
DOIs
Publication statusPublished - 2013 Jul
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology (medical)

Fingerprint

Dive into the research topics of 'The lower safety level of blood pressure evaluated by <sup>123</sup>I-IMP single-photon emission computed tomography in acute cerebral infarction patients'. Together they form a unique fingerprint.

Cite this