The ken and barbie gene encoding a putative transcription factor with a BTB domain and three zinc finger motifs functions in terminalia development of Drosophila

Tamas Lukacsovich, Kazuya Yuge, Wakae Awano, Zoltan Asztalos, Shunzo Kondo, Naoto Juni, Daisuke Yamamoto

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)

    Abstract

    Mutations in the ken and barbie locus are accompanied by the malformation of terminalia in adult Drosophila. Male and female genitalia often remain inside the body, and the same portions of genitalia and analia are missing in a fraction of homozygous flies. Rotated and/or duplicated terminalia are also observed. Terminalia phenotypes are enhanced by mutations in the gap gene tailless, the homeobox gene caudal, and the decapentaplegic gene that encodes a TGFβ-like morphogen. The ken and barbie gene encodes a protein with three CCHH-type zinc finger motifs that are conserved in several transcription factors such as Krüppel and BCL-6. All defects in ken and barbie mutants are fully rescued by the expression of a wild-type genomic construct, which establishes the causality between phenotypes ond the gene.

    Original languageEnglish
    Pages (from-to)77-94
    Number of pages18
    JournalArchives of Insect Biochemistry and Physiology
    Volume54
    Issue number2
    DOIs
    Publication statusPublished - 2003 Oct 1

    Keywords

    • Caudal
    • Genital disc
    • Morphogensis
    • TGF-β
    • Tailless

    ASJC Scopus subject areas

    • Physiology
    • Biochemistry
    • Insect Science

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