The Keap1/Nrf2 protein axis plays a role in osteoclast differentiation by regulating intracellular reactive oxygen species signaling

Hiroyuki Kanzaki, Fumiaki Shinohara, Mikihito Kajiya, Tetsuya Kodama

Research output: Contribution to journalArticlepeer-review

81 Citations (Scopus)

Abstract

Background: Nuclear factor E2-related factor 2 (Nrf2) is a master regulator of cytoprotective enzymes. Results: Nrf2 overexpression-mediated cytoprotective enzymes' augmentation blocked RANKL signaling via intracellular ROS attenuation and thereby blocked bone destruction. Conclusion: Nrf2-dependent cytoprotective enzyme expressions play a role in the regulation of osteoclastogenesis by controlling intracellular ROS. Significance: The Keap1/Nrf2 axis could be a novel therapeutic target for the treatment of bone destructive disease.

Original languageEnglish
Pages (from-to)23009-23020
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number32
DOIs
Publication statusPublished - 2013 Aug 9

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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