The isotropic-nematic transition and the phase separation of the tobacco mosaic virus particles with polysaccharide

Naohito Urakami, Masayuki Imai, Yoh Sano, Masako Takasu

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

The isotropic-nematic transition of the tobacco mosaic virus (TMV) particles by polysaccharide is related to a high inhibitory activity against TMV infection. We study the process of the isotropic-nematic transition of the TMV particles as a function of the polysaccharide concentration by Monte Carlo simulations in three-dimensional continuous space. In these simulations, we simplify the TMV particles and the polysaccharide molecules as the hard spherocylinders and semirigid chains, respectively, and we assume the simple interactions for the TMV particles and the polysaccharide chains. In our simulation, with increasing concentration of the polysaccharide the homogeneously dispersed TMV particles begin to segregate without orientational ordering, that is isotropic phase separation, and then transform to the nematic state of the TMV particles. The isotropic-nematic transition is caused by simple interactions such as the excluded volume effect, and the complicated biological interaction is not necessary.

Original languageEnglish
Pages (from-to)2322-2328
Number of pages7
JournalJournal of Chemical Physics
Volume111
Issue number5
DOIs
Publication statusPublished - 1999 Aug 1
Externally publishedYes

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry

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