TY - JOUR
T1 - The investigation of acute optic neuritis
T2 - A review and proposed protocol
AU - Petzold, Axel
AU - Wattjes, Mike P.
AU - Costello, Fiona
AU - Flores-Rivera, Jose
AU - Fraser, Clare L.
AU - Fujihara, Kazuo
AU - Leavitt, Jacqueline
AU - Marignier, Romain
AU - Paul, Friedemann
AU - Schippling, Sven
AU - Sindic, Christian
AU - Villoslada, Pablo
AU - Weinshenker, Brian
AU - Plant, Gordon T.
N1 - Funding Information:
The MS Center VUMC is partially funded by a programme grant from the Dutch MS Research Foundation. K.F. is a recipient of Grants-in-Aid for Scientific Research from the Ministry of Education, Science and Technology and the Ministry of Health, Labour and Welfare of Japan. F.P. is supported by the German Research Council (DFG Exc 257) and the German Ministry for Education and Research Competence Network Multiple Sclerosis. S.S. is supported by the Clinical Research Priority Program of the University of Zürich and the Betty and David Koetser Foundation for Brain Research. G.T.P. is supported by the University College London Comprehensive Biomedical Research Centre and the Moorfields Biomedical Research Centre.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/8
Y1 - 2014/8
N2 - Optic neuritis is an inflammatory optic neuropathy that affects many patients with multiple sclerosis (MS) at some point during their disease course. Differentiation of acute episodes of MS-associated optic neuritis from other autoimmune and inflammatory optic neuropathies is vital for treatment choice and further patient management, but is not always straightforward. Over the past decade, a number of new imaging, laboratory and electrophysiological techniques have entered the clinical arena. To date, however, no consensus guidelines have been devised to specify how and when these techniques can be most rationally applied for the diagnostic work-up of patients with acute optic neuritis. In this article, we review the literature and attempt to formulate a consensus for the investigation of patients with acute optic neuritis, both in standard care and in research with relevance to clinical treatment trials.
AB - Optic neuritis is an inflammatory optic neuropathy that affects many patients with multiple sclerosis (MS) at some point during their disease course. Differentiation of acute episodes of MS-associated optic neuritis from other autoimmune and inflammatory optic neuropathies is vital for treatment choice and further patient management, but is not always straightforward. Over the past decade, a number of new imaging, laboratory and electrophysiological techniques have entered the clinical arena. To date, however, no consensus guidelines have been devised to specify how and when these techniques can be most rationally applied for the diagnostic work-up of patients with acute optic neuritis. In this article, we review the literature and attempt to formulate a consensus for the investigation of patients with acute optic neuritis, both in standard care and in research with relevance to clinical treatment trials.
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U2 - 10.1038/nrneurol.2014.108
DO - 10.1038/nrneurol.2014.108
M3 - Review article
C2 - 25002105
AN - SCOPUS:84906101670
VL - 10
SP - 447
EP - 458
JO - Nature Reviews Neurology
JF - Nature Reviews Neurology
SN - 1759-4758
IS - 8
ER -