The international database of home blood pressure in relation to cardiovascular outcome (IDHOCO): Moving from baseline characteristics to research perspectives

Teemu J. Niiranen, Lutgarde Thijs, Kei Asayama, Jouni K. Johansson, Takayoshi Ohkubo, Masahiro Kikuya, José Boggia, Atsushi Hozawa, Edgardo Sandoya, George S. Stergiou, Ichiro Tsuji, Antti M. Jula, Yutaka Imai, Jan A. Staessen

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

The objective of this study is to construct an International Database of HOme blood pressure in relation to Cardiovascular Outcome (IDHOCO). The main goal of this database is to determine outcome-based diagnostic thresholds for the self-measured home blood pressure (BP). Secondary objectives include investigating the predictive value of white-coat and masked hypertension, morning and evening BP, BP and heart rate variability, and the home arterial stiffness index. We also aim to determine an optimal schedule for home BP measurements that provides the most accurate risk stratification. Eligible studies are population-based, have fatal as well as nonfatal outcomes available for analysis, comply with ethical standards, and have been previously published in peer-reviewed journals. In a meta-analysis based on individual subject data, composite and cause-specific cardiovascular events will be related to various indexes derived by home BP measurement. The analyses will be stratified by a cohort and adjusted for the clinic BP and established cardiovascular risk factors. The database includes 6753 subjects from five cohorts recruited in Ohasama, Japan (n2777); Finland (n2075); Tsurugaya, Japan (n836); Didima, Greece (n665); and Montevideo, Uruguay (n400). In these five cohorts, during a total of 62 106 person-years of follow-up (mean 9.2 years), 852 subjects died and 740 participants experienced a fatal or nonfatal cardiovascular event. IDHOCO provides a unique opportunity to investigate several hypotheses that could not reliably be studied in individual studies. The results of these analyses should be of help to clinicians involved in the management of patients with suspected or established hypertension.

Original languageEnglish
Pages (from-to)1072-1079
Number of pages8
JournalHypertension Research
Volume35
Issue number11
DOIs
Publication statusPublished - 2012 Nov

Keywords

  • BP measurement
  • epidemiology
  • home
  • self-measurement

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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