The insulin-like growth factor II receptor gene is mutated in genetically unstable cancers of the endometrium, stomach, and colorectum

Hong Ouyang, Hiromi O. Shiwaku, Hisashi Hagiwara, Ko Miura, Tadayoshi Abe, Yo Kato, Haruo Ohtani, Kenichi Shiiba, Rhonda F. Souza, Stephen J. Meltzer, Akira Horii

Research output: Contribution to journalArticlepeer-review

166 Citations (Scopus)

Abstract

Disruption of the DNA mismatch repair system, characterized by microsatellite instability (MI), plays an important role in the course of human carcinogenesis. Repetitive sequences constitute targets for mutation in MI+ cells, and frequent mutations have indeed been reported in such regions within the transforming growth factor β receptor II (RII) gene in genetically unstable colorectal and gastric cancers. However, other genes that are targets for mutations in MI+ cells during the course of carcinogenesis have proven elusive. Because the insulin-like growth factor II receptor (IGFIIR) gene contains several repetitive sequences within its coding region, we examined mutations of this gene in MI+ cancers occurring at various primary sites. We found frameshift mutations in the poly(G)8 tract of IGFIIR in eight tumors, all of which were MI+: 4 of 26 (15%) MI + endometrial cancers, 3 of 12 (25%) MI + gastric cancers, and 1 of 18 (6%) MI+ colorectal cancers. In contrast, no mutation was found in 51 pancreatic cancers, 7 of which (14%) were MI+. These results implicate abnormal IGFIIR- mediated growth control in carcinogenesis involving the endometrium, stomach, and colorectum but not the pancreas.

Original languageEnglish
Pages (from-to)1851-1854
Number of pages4
JournalCancer Research
Volume57
Issue number10
Publication statusPublished - 1997 May 15

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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