The inner blood-retinal barrier molecular structure and transport biology

Ken Ichi Hosoya, Masanori Tachikawa

Research output: Chapter in Book/Report/Conference proceedingChapter

63 Citations (Scopus)


The inner blood-retinal barrier (inner BRB) is created by complex tight junctions of retinal capillary endothelial cells. Although this barrier prevents the free diffusion of substances between the circulating blood and the neural retina, the inner BRB efficiently supplies nutrients to the retina and removes endobiotics and xenobiotics from the retina to maintain a constant milieu in the neural retina. We review herein the molecular structure and transport mechanism at the inner BRB.

Original languageEnglish
Title of host publicationBiology and Regulation of Blood-Tissue Barriers
PublisherSpringer New York LLC
Number of pages20
ISBN (Print)9781461447108
Publication statusPublished - 2013

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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