The inhibitory effects of oligonucleotides, complementary to Marek's disease virus mRNA transcribed from the BamHI-H region, on the proliferation of transformed lymphoblastoid cells, MDCC-MSB1

M. Kawamura, M. Hayashi, T. Furuichi, M. Nonoyama, E. Isogai, S. Namioka

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35 Citations (Scopus)

Abstract

An oligonucleotide complementary to the splice donor sequence of the 1.8 kb gene family produced from the BamHI-H region of Marek's disease virus (MDV) DNA inhibited the proliferation of the MDV-derived lymphoblastoid cell line, MDCC-MSB 1 (MSB-1), but not that of the avian lymphoid leukosis-derived lymphoblastoid cell line, LSCC-BK3. Colony formation in soft agar was also inhibited by treatment of MSB-1 cells with the antisense oligonucleotide. It is hypothesized that expression of the 1.8 kb gene family produced from the BamHI-H region is directly associated with the maintenance of the tumorigenic state of transformed Marek's disease-derived lymphoblastoid cells.

Original languageEnglish
Pages (from-to)1105-1111
Number of pages7
JournalJournal of General Virology
Volume72
Issue number5
DOIs
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Virology

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