The inhibitory effects of oligonucleotides, complementary to Marek's disease virus mRNA transcribed from the BamHI-H region, on the proliferation of transformed lymphoblastoid cells, MDCC-MSB1

M. Kawamura; M. Hayashi; T. Furuichi; M. Nonoyama; E. Isogai; S. Namioka

doi:10.1099/0022-1317-72-5-1105

The inhibitory effects of oligonucleotides, complementary to Marek's disease virus mRNA transcribed from the BamHI-H region, on the proliferation of transformed lymphoblastoid cells, MDCC-MSB1

M. Kawamura, M. Hayashi, T. Furuichi, M. Nonoyama, E. Isogai, S. Namioka

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

An oligonucleotide complementary to the splice donor sequence of the 1.8 kb gene family produced from the BamHI-H region of Marek's disease virus (MDV) DNA inhibited the proliferation of the MDV-derived lymphoblastoid cell line, MDCC-MSB 1 (MSB-1), but not that of the avian lymphoid leukosis-derived lymphoblastoid cell line, LSCC-BK3. Colony formation in soft agar was also inhibited by treatment of MSB-1 cells with the antisense oligonucleotide. It is hypothesized that expression of the 1.8 kb gene family produced from the BamHI-H region is directly associated with the maintenance of the tumorigenic state of transformed Marek's disease-derived lymphoblastoid cells.

Original language	English
Pages (from-to)	1105-1111
Number of pages	7
Journal	Journal of General Virology
Volume	72
Issue number	5
DOIs	https://doi.org/10.1099/0022-1317-72-5-1105
Publication status	Published - 1991
Externally published	Yes

ASJC Scopus subject areas

Virology

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Kawamura, M., Hayashi, M., Furuichi, T., Nonoyama, M., Isogai, E., & Namioka, S. (1991). The inhibitory effects of oligonucleotides, complementary to Marek's disease virus mRNA transcribed from the BamHI-H region, on the proliferation of transformed lymphoblastoid cells, MDCC-MSB1. Journal of General Virology, 72(5), 1105-1111. https://doi.org/10.1099/0022-1317-72-5-1105

The inhibitory effects of oligonucleotides, complementary to Marek's disease virus mRNA transcribed from the BamHI-H region, on the proliferation of transformed lymphoblastoid cells, MDCC-MSB1. / Kawamura, M.; Hayashi, M.; Furuichi, T. et al.

In: Journal of General Virology, Vol. 72, No. 5, 1991, p. 1105-1111.

Research output: Contribution to journal › Article › peer-review

Kawamura, M, Hayashi, M, Furuichi, T, Nonoyama, M, Isogai, E & Namioka, S 1991, 'The inhibitory effects of oligonucleotides, complementary to Marek's disease virus mRNA transcribed from the BamHI-H region, on the proliferation of transformed lymphoblastoid cells, MDCC-MSB1', Journal of General Virology, vol. 72, no. 5, pp. 1105-1111. https://doi.org/10.1099/0022-1317-72-5-1105

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abstract = "An oligonucleotide complementary to the splice donor sequence of the 1.8 kb gene family produced from the BamHI-H region of Marek's disease virus (MDV) DNA inhibited the proliferation of the MDV-derived lymphoblastoid cell line, MDCC-MSB 1 (MSB-1), but not that of the avian lymphoid leukosis-derived lymphoblastoid cell line, LSCC-BK3. Colony formation in soft agar was also inhibited by treatment of MSB-1 cells with the antisense oligonucleotide. It is hypothesized that expression of the 1.8 kb gene family produced from the BamHI-H region is directly associated with the maintenance of the tumorigenic state of transformed Marek's disease-derived lymphoblastoid cells.",

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The inhibitory effects of oligonucleotides, complementary to Marek's disease virus mRNA transcribed from the BamHI-H region, on the proliferation of transformed lymphoblastoid cells, MDCC-MSB1

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