The inhibitory effects of catechins on biofilm formation by the periodontopathogenic bacterium, Eikenella corrodens

Tetsuro Matsunaga, Aya Nakahara, Karim M. Minnatul, Yuichiro Noiri, Shigeyuki Ebisu, Akio Kato, Hiroyuki Azakami

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

Eikenella corrodens is a periodontopathogenic bacterium that forms biofilm even by itself. In this study, we investigated the inhibitory effects of catechins on E. corrodens biofilm formation. Biofilm formation was inhibited by the addition of 1mM of the catechins with the pyrogallol-type B-ring and/or the galloyl group. The catechins with the galloyl group were effective at smaller doses than those with only the pyrogallol-type B-ring. An inhibitory effect was observed even when these catechins and gallic acid were added at subminimal inhibitory concentration (MIC) or at concentrations that showed no bactericidal effect. These results suggest that some catechins at sub-MIC might inhibit biofilm formation. No inhibitory effect of catechins at sub-MIC on biofilm formation was observed in the luxS deletion mutant. Our studies suggest that some species of catechins with the galloyl group affect autoinducer 2-mediated quorum sensing and thereby inhibit biofilm formation by E. corrodens.

Original languageEnglish
Pages (from-to)2445-2450
Number of pages6
JournalBioscience, Biotechnology and Biochemistry
Volume74
Issue number12
DOIs
Publication statusPublished - 2010
Externally publishedYes

Keywords

  • Biofilm
  • Catechin
  • Periodontal disease

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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