The inhibitory effect of substance P antagonist, CP-96,345, on the late discharges of nociceptive neurons in the rat superficial spinal dorsal horn

Takashi Toda, Haruhide Hayashi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The effects of local spinal applications of the substance P antagonist, CP-96,345, on the electrically-evoked discharges of nociceptive neurons were examined in the superficial spinal dorsal horn of adult rats anesthetized with sodium pentobarbital. Extracellular single-unit recordings were made from lumbar spinal dorsal horn neurons which were excited by noxious mechanical stimulation and had early and late discharges evoked by A- and C-fiber inputs, respectively, following transcutaneous electrical stimulation. CP-96,345 was applied directly onto the surface of the spinal cord close to the recording sites. A dose of 50 nmol of CP-96,345 drastically inhibited the late discharges of 80% of neurons, without affecting early discharges significantly. This study demonstrated the specific inhibitory effect of CP-96,345 on the late discharges of a restricted population of spinal dorsal horn neurons. These results illustrate the important role of substance P in nociceptive transmission mediated by primary afferent C-fibers in normal acute pain.

Original languageEnglish
Pages (from-to)36-38
Number of pages3
JournalNeuroscience Letters
Volume158
Issue number1
DOIs
Publication statusPublished - 1993 Aug 6

Keywords

  • C-fiber
  • CP-96,345
  • NK-1
  • Pain
  • Spinal dorsal horn neuron
  • Substance P

ASJC Scopus subject areas

  • Neuroscience(all)

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