TY - JOUR
T1 - The inhibition effect of antiserum on the motility of leptospira
AU - Guo, Yijie
AU - Nakamura, Shuichi
AU - Ando, Tasuke
AU - Yoneyama, Hiroshi
AU - Kudo, Seishi
AU - Isogai, Emiko
PY - 2013/4/1
Y1 - 2013/4/1
N2 - Leptospires are a group of bacteria with a unique ultrastructure and a fascinating swimming behavior that cause a number of emerging and re-emerging diseases worldwide called leptospirosis. The unusual form of motility is thought to play a critical role in the infection process. However, the inhibition mechanism of antiserum on the motility of Leptospira to attenuate the infection efficiency is unknown. In this study, effect of antiserum on motility was quantitatively investigated by swimming speed. Relatively low concentration of antiserum was found to inhibit leptospiral motility, suggesting that the basic immunization can affect the infection efficiency. Recovery of motility a few hours later after the addition of antiserum was observed. This raises a hypothesis that Leptospira carries surface molecules bound with antibodies toward the cell end to escape and recovers the motility.
AB - Leptospires are a group of bacteria with a unique ultrastructure and a fascinating swimming behavior that cause a number of emerging and re-emerging diseases worldwide called leptospirosis. The unusual form of motility is thought to play a critical role in the infection process. However, the inhibition mechanism of antiserum on the motility of Leptospira to attenuate the infection efficiency is unknown. In this study, effect of antiserum on motility was quantitatively investigated by swimming speed. Relatively low concentration of antiserum was found to inhibit leptospiral motility, suggesting that the basic immunization can affect the infection efficiency. Recovery of motility a few hours later after the addition of antiserum was observed. This raises a hypothesis that Leptospira carries surface molecules bound with antibodies toward the cell end to escape and recovers the motility.
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U2 - 10.1007/s00284-012-0281-6
DO - 10.1007/s00284-012-0281-6
M3 - Article
C2 - 23224413
AN - SCOPUS:84878385875
VL - 66
SP - 359
EP - 364
JO - Current Microbiology
JF - Current Microbiology
SN - 0343-8651
IS - 4
ER -