The influence of ileo-jejunal transposition on intestinal mucosal growth and gut hormones after total colectomy

T. Tsuchiya, I. Sasaki, H. Naito, H. Narui, Y. Funayama, Y. Suzuki, M. Toda

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Abstract

To clarify the effect of ileo-jejunal transposition on intestinal mucosal height and gut hormones, canine models undergoing total colectomy either with transection of the small intestine (control group) or ileo-jejunal transposition (transposition group) were compared, and the following results were obtained. There was no difference in body weight between control group and transposition group 18 weeks after operation. Significant increase of mucosal height was observed in transposition group but not in control group. Plasma levels of total GLI were significantly higher in transposition group but not in control group, whereas a count of GLI secreting cell was not changed in both groups. Plasma levels of gastrin after test meal were lower in transposition group than in control group. These results indicated that ileo-jejunal transposition induces hyperenteroglucagonemia, which may play an important role in intestinal adaptation after colectomy.

Original languageEnglish
Pages (from-to)870-877
Number of pages8
JournalNippon Geka Gakkai zasshi
Volume87
Issue number8
Publication statusPublished - 1986 Aug

ASJC Scopus subject areas

  • Medicine(all)

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    Tsuchiya, T., Sasaki, I., Naito, H., Narui, H., Funayama, Y., Suzuki, Y., & Toda, M. (1986). The influence of ileo-jejunal transposition on intestinal mucosal growth and gut hormones after total colectomy. Nippon Geka Gakkai zasshi, 87(8), 870-877.