The increase of plasma galectin-9 in a patient with insulin allergy: A case report

Haorile Chagan-Yasutan, Beata Shiratori, Umme R. Siddiqi, Hiroki Saitoh, Yugo Ashino, Tomohiro Arikawa, Mitsuomi Hirashima, Toshio Hattori

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Allergic reaction to insulin is known to be associated with eosinophilia and hyper IgE. Recent report showed that eosinophilia is related with the increased synthesis of galectin-9 (GAL-9) and osteopontin (OPN). Here, we examined plasma levels of GAL-9 and OPN first time in a case of 65-year old patient with insulin allergy. Insulin aspart & insulin aspart 30 mix were given to the patient and an elevation of the eosinophil count (8440/μl, 17.6 fold) and a moderate increase of IgE (501 U/ml, reference range: 10-350 U/ml), eotaxin-3 (168 pg/ml, 2 fold), histamine (0.95 ng/ml, 5.3 fold) were found 33 days later. The plasma levels of GAL-9 and OPN were 22.5 and 1.7 fold higher than the cut-off point, respectively. After one month cessation of insulin therapy, elevations of the eosinophil count (3,480/μl; 7.3 fold), and OPN (1.4 fold) still occurred but the GAL-9 levels became normal. Therefore, we noted the increases of GAL-9 and OPN in plasma for the first time in a patient with insulin allergy and propose that GAL-9 reflects the conditions of allergy more accurately.

Original languageEnglish
Article number12
JournalClinical and Molecular Allergy
Publication statusPublished - 2010 Aug 11

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Molecular Biology


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