TY - JOUR
T1 - The increase of plasma galectin-9 in a patient with insulin allergy
T2 - A case report
AU - Chagan-Yasutan, Haorile
AU - Shiratori, Beata
AU - Siddiqi, Umme R.
AU - Saitoh, Hiroki
AU - Ashino, Yugo
AU - Arikawa, Tomohiro
AU - Hirashima, Mitsuomi
AU - Hattori, Toshio
N1 - Funding Information:
This report was supported by collaborative funding from the Research Center for Zoonosis Control, Hokkaido University. We are grateful to Prof. Hideki Katagiri for critical reading of the manuscript.
PY - 2010/8/11
Y1 - 2010/8/11
N2 - Allergic reaction to insulin is known to be associated with eosinophilia and hyper IgE. Recent report showed that eosinophilia is related with the increased synthesis of galectin-9 (GAL-9) and osteopontin (OPN). Here, we examined plasma levels of GAL-9 and OPN first time in a case of 65-year old patient with insulin allergy. Insulin aspart & insulin aspart 30 mix were given to the patient and an elevation of the eosinophil count (8440/μl, 17.6 fold) and a moderate increase of IgE (501 U/ml, reference range: 10-350 U/ml), eotaxin-3 (168 pg/ml, 2 fold), histamine (0.95 ng/ml, 5.3 fold) were found 33 days later. The plasma levels of GAL-9 and OPN were 22.5 and 1.7 fold higher than the cut-off point, respectively. After one month cessation of insulin therapy, elevations of the eosinophil count (3,480/μl; 7.3 fold), and OPN (1.4 fold) still occurred but the GAL-9 levels became normal. Therefore, we noted the increases of GAL-9 and OPN in plasma for the first time in a patient with insulin allergy and propose that GAL-9 reflects the conditions of allergy more accurately.
AB - Allergic reaction to insulin is known to be associated with eosinophilia and hyper IgE. Recent report showed that eosinophilia is related with the increased synthesis of galectin-9 (GAL-9) and osteopontin (OPN). Here, we examined plasma levels of GAL-9 and OPN first time in a case of 65-year old patient with insulin allergy. Insulin aspart & insulin aspart 30 mix were given to the patient and an elevation of the eosinophil count (8440/μl, 17.6 fold) and a moderate increase of IgE (501 U/ml, reference range: 10-350 U/ml), eotaxin-3 (168 pg/ml, 2 fold), histamine (0.95 ng/ml, 5.3 fold) were found 33 days later. The plasma levels of GAL-9 and OPN were 22.5 and 1.7 fold higher than the cut-off point, respectively. After one month cessation of insulin therapy, elevations of the eosinophil count (3,480/μl; 7.3 fold), and OPN (1.4 fold) still occurred but the GAL-9 levels became normal. Therefore, we noted the increases of GAL-9 and OPN in plasma for the first time in a patient with insulin allergy and propose that GAL-9 reflects the conditions of allergy more accurately.
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U2 - 10.1186/1476-7961-8-12
DO - 10.1186/1476-7961-8-12
M3 - Article
C2 - 20699002
AN - SCOPUS:77955406114
SN - 1476-7961
VL - 8
JO - Clinical and Molecular Allergy
JF - Clinical and Molecular Allergy
M1 - 12
ER -