TY - JOUR
T1 - The impact of intrauterine treatment on fetal tachycardia
T2 - a nationwide survey in Japan
AU - on behalf of Japan Fetal Arrhythmia Group
AU - Ueda, Keiko
AU - Maeno, Yasuki
AU - Miyoshi, Takekazu
AU - Inamura, Noboru
AU - Kawataki, Motoyoshi
AU - Taketazu, Mio
AU - Nii, Masaki
AU - Hagiwara, Akiko
AU - Horigome, Hitoshi
AU - Shozu, Makio
AU - Shimizu, Wataru
AU - Yasukochi, Satoshi
AU - Yoda, Hitoshi
AU - Shiraishi, Isao
AU - Sakaguchi, Heima
AU - Katsuragi, Shinji
AU - Sago, Haruhiko
AU - Ikeda, Tomoaki
N1 - Funding Information:
This study was supported by a grant from the Ministry of Health, Labour and Welfare, Japan (Health and Labour Science Research Grants for Clinical Research for New Medicine) (H19-009).
Publisher Copyright:
© 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2018/10/2
Y1 - 2018/10/2
N2 - Objectives: To investigate the clinical course of fetal tachycardia and analyze the impact of intrauterine treatment on the postnatal treatment and patient outcomes. Study design: This was a retrospective review of cases of fetal tachycardia that occurred from 2004 to 2006. Data were collected from questionnaires that were sent to all 750 secondary or tertiary perinatal care centers in Japan. Results: Eighty-two cases (14 with fetal hydrops) were analyzed (supraventricular tachycardia [SVT], n = 52; atrial flutter [AFL], n = 23; and ventricular tachycardia, n = 7). The overall mortality was 3.7%. Intrauterine treatment was performed for 41 fetuses (50.0%). Digoxin, flecainide and sotalol were mainly used for SVT and AFL. Fetal tachycardia resolved in 90.0% (27/30) of the cases without fetal hydrops and 90.9% (10/11) of the cases with fetal hydrops. Intrauterine treatment significantly reduced the incidence of cesarean delivery (29.3 vs. 70.7%, p <.01), preterm birth (12.2 vs. 41.5%, p =.02) and neonatal arrhythmias (48.8 vs. 78.0%, p =.01) in comparison to untreated fetuses. Conclusions: This nationwide survey revealed that intrauterine treatment was performed for approximately half of the cases of fetal tachycardia and was associated with lower rates of cesarean delivery, premature birth and neonatal arrhythmias in comparison to untreated fetuses.
AB - Objectives: To investigate the clinical course of fetal tachycardia and analyze the impact of intrauterine treatment on the postnatal treatment and patient outcomes. Study design: This was a retrospective review of cases of fetal tachycardia that occurred from 2004 to 2006. Data were collected from questionnaires that were sent to all 750 secondary or tertiary perinatal care centers in Japan. Results: Eighty-two cases (14 with fetal hydrops) were analyzed (supraventricular tachycardia [SVT], n = 52; atrial flutter [AFL], n = 23; and ventricular tachycardia, n = 7). The overall mortality was 3.7%. Intrauterine treatment was performed for 41 fetuses (50.0%). Digoxin, flecainide and sotalol were mainly used for SVT and AFL. Fetal tachycardia resolved in 90.0% (27/30) of the cases without fetal hydrops and 90.9% (10/11) of the cases with fetal hydrops. Intrauterine treatment significantly reduced the incidence of cesarean delivery (29.3 vs. 70.7%, p <.01), preterm birth (12.2 vs. 41.5%, p =.02) and neonatal arrhythmias (48.8 vs. 78.0%, p =.01) in comparison to untreated fetuses. Conclusions: This nationwide survey revealed that intrauterine treatment was performed for approximately half of the cases of fetal tachycardia and was associated with lower rates of cesarean delivery, premature birth and neonatal arrhythmias in comparison to untreated fetuses.
KW - Antiarrhythmic drugs
KW - fetal tachycardia
KW - intrauterine treatment
KW - prenatal diagnosis
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U2 - 10.1080/14767058.2017.1350159
DO - 10.1080/14767058.2017.1350159
M3 - Article
AN - SCOPUS:85025168331
VL - 31
SP - 2605
EP - 2610
JO - Journal of Maternal-Fetal and Neonatal Medicine
JF - Journal of Maternal-Fetal and Neonatal Medicine
SN - 1476-7058
IS - 19
ER -