The immunoregulatory effects of NK cells: The role of TGF-β and implications for auto im m unity

David A. Horwitz, J. Dixon Gray, Kazuo Ohtsuka, Makoto Hirokawa, Tetsu Takahashi

Research output: Contribution to journalComment/debatepeer-review

88 Citations (Scopus)

Abstract

The cytotoxic activities of natural killer (NK) cells - important in innate immunity - have received considerable attention, but. NK cells also regulate T- and B-cell functions as well as hematopoiesis. Here, David Honvitz and colleagues focus on the capacity of NK cells to regulate antibody production positively and negatively, and in particular on the role of NK-cell transforming groiuth factor (TGF-) in ! doumregulation of B-cell activity.

Original languageEnglish
Pages (from-to)538-542
Number of pages5
JournalImmunology Today
Volume18
Issue number11
DOIs
Publication statusPublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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