The immunological roles of periostin/tumor-associated macrophage axis in development of dermatofibrosarcoma protuberans

Taku Fujimura, Aya Kakizaki, Yota Sato, Kayo Tanita, Sadanori Furudate, Setsuya Aiba

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Background/Aim: Dermatofibrosarcoma protuberance (DFSP) is a fibrohistiocytic tumor of intermediate malignancy characterized by slow infiltrative growth and a high tendency to recur locally. Periostin is involved in modulating cell function and inducing the production of proinflammatory cytokines, chemokines, and matrix metalloproteinases (MMPs) from tumor-associated macrophages (TAMs) to promote fibrosis and tumor growth. This study aimed to examine the cancer stroma of DFSP, focusing on TAMs-related proteins and MMPs. Patients and Methods: Using immunohistochemical staining and DNA microarray database, we evaluated periostin, CD163, CD206, MMP1 and MMP12 in 10 cases of DFSP and dermatofibroma. Results: Dense deposits of periostin as well as a substantial number of CD163+ TAMs were detected at the peripheral areas of DFSP. Moreover, MMP1 and MMP12, that were selected by using a DNA microarray database of monocyte-derived macrophages, were observed in the TAMsdetected area. Conclusion: Increased levels of MMP1 and MMP12 on TAMs in the peripheral areas of DFSP might contribute to local invasion.

Original languageEnglish
Pages (from-to)2867-2873
Number of pages7
JournalAnticancer research
Volume37
Issue number6
DOIs
Publication statusPublished - 2017 Jun

Keywords

  • DFSP
  • MMP1
  • MMP12
  • Periostin
  • Tumor-associated macrophages

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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