The immunohistochemical evaluation of PSP/reg-protein in normal and diseased human pancreatic tissues

Yoshitake Satomura, Norio Sawabu, Hideki Ohta, Hiroyuki Watanabe, Osamu Yamakawa, Yoshiharu Motoo, Takashi Okai, Daishu Toya, Hiroshi Makino, Hiroshi Okamoto

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35 Citations (Scopus)

Abstract

In order to elucidate the characteristics of reg-protein, which is identical to pancreatic stone protein (PSP/reg-protein), and the relationship between the generation and evolution of chronic pancreatitis and the expression of PSP/reg-protein in the pancreas, we investigated the expression of PSP/reg-protein in normal and diseased human pancreatic tissues by immunohistochemistry. The PSP/reg-protein was expressed in all cases with normal pancreas or chronic pancreatitis, and in 70.6% of cases with pancreatic cancer. This protein was present in the cytoplasm of acinar cells and, in some cases, in the intraluminal contents of ductules in nonmalignant tissues. From the view of distribution and cellular localization, PSP/reg-protein was expressed more broadly and densely in chronic pancreatitis with mild to moderate injury than in the normal pancreas. However, the protein was less expressed in severely damaged chronic pancreatitis tissue, such as calcifying pancreatitis, than in the normal pancreas. These findings suggest that mild to moderate injury to pancreatic tissue may stimulate the synthesis of PSP/reg-protein, whereas more severe injury tends to depress it.

Original languageEnglish
Pages (from-to)59-67
Number of pages9
JournalInternational Journal of Pancreatology
Volume13
Issue number1
DOIs
Publication statusPublished - 1993 Feb 1

Keywords

  • PSP/reg-protein
  • Pancreatic stone protein
  • chronic pancreatitis
  • pancreatic calculi
  • pancreatic cancer

ASJC Scopus subject areas

  • Oncology
  • Endocrinology
  • Gastroenterology

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  • Cite this

    Satomura, Y., Sawabu, N., Ohta, H., Watanabe, H., Yamakawa, O., Motoo, Y., Okai, T., Toya, D., Makino, H., & Okamoto, H. (1993). The immunohistochemical evaluation of PSP/reg-protein in normal and diseased human pancreatic tissues. International Journal of Pancreatology, 13(1), 59-67. https://doi.org/10.1007/BF02795200