The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction

Norihiko Ohbayashi, Shiho Kawakami, Ryuta Muromoto, Sumihito Togi, Osamu Ikeda, Shinya Kamitani, Yuichi Sekine, Tsutomu Honjoh, Tadashi Matsuda

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)

    Abstract

    Post-translational modification by small ubiquitin-like modifier (SUMO) plays an important role in the regulation of different signaling pathways and is involved in the formation of promyelocytic leukemia (PML) protein nuclear bodies following sumoylation of PML. In the present study, we found that IL-6 induces desumoylation of PML and dissociation between PML and SUMO1 in hepatoma cells. We also found that IL-6 induces mRNA expression of SENP1, a member of the SUMO-specific protease family. Furthermore, wild-type SENP1 but not an inactive SENP1 mutant restored the PML-mediated suppression of STAT3 activation. These results indicate that the IL-6 family of cytokines modulates STAT3 activation by desumoylation and inactivation PML through SENP1 induction.

    Original languageEnglish
    Pages (from-to)823-828
    Number of pages6
    JournalBiochemical and biophysical research communications
    Volume371
    Issue number4
    DOIs
    Publication statusPublished - 2008 Jul 11

    Keywords

    • IL-6
    • LIF
    • PML
    • SENP1
    • STAT3
    • SUMO
    • Transcriptional regulation

    ASJC Scopus subject areas

    • Biophysics
    • Biochemistry
    • Molecular Biology
    • Cell Biology

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