The Hypotensive and Cardiac Hemodynamic Effects of Metoprolol, an β1-selective Adrenergic β-Receptor Blocking Agent, in Essential Hypertensive Patients

Yutaka Imai, Masao Hiwatari, Keishi Abe, Kaoru Yoshinaga

Research output: Contribution to journalArticlepeer-review

Abstract

The hypotensive effect of metoprolol at doses from 60 to 120 mg/day was studied in 10 patients with mild to moderate essential hypertension (4 males and 6 females, the average 55.6±9.7 years old). The effects of metoprolol on hemodynamics (9 cases) and plasma renin activity (7 cases) were simultaneously studied in these patients. The hypotensive effect of metoprolol was rapid, and was more marked in diastolic than in systolic. Metoprolol decreased the diastolic blood pressure significantly from 103.7±8.8 mmHg (Mean±S. D.) in supine position before administration to 97.6±8.8 mmHg in the second week. The hypotensive effect continued for some time afterwards, and even in the 10 th week the diastolic blood pressure recorded 92.0 ±11.1 mmHg. Metoprolol caused significant decrease in the pulse rate. Dose of metoprolol was increased in 3 cases, in one of which the hypotensive effect tended to increase further. In 2 cases with chronic obstructive airway disease, the administration of metoprolol did not aggravate the symptoms. In 3 out of 9 cases, metoprolol induced.

Original languageEnglish
Pages (from-to)239-247
Number of pages9
JournalRinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
Volume11
Issue number3
DOIs
Publication statusPublished - 1980

Keywords

  • cardiac output
  • metoprolol
  • plasma renin renin activity
  • total peripheral resistance
  • treatment of essential hypertension

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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