The human cathelicidin antimicrobial peptide LL-37 and mimics are potential anticancer drugs

Kengo Kuroda, Kazuhiko Okumura, Hiroshi Isogai, Emiko Isogai

Research output: Contribution to journalReview articlepeer-review

56 Citations (Scopus)

Abstract

Antimicrobial peptides (AMPs) play a critical role in innate host defense against microbial pathogens in many organisms. The human cathelicidin, LL-37, has a net positive charge and is amphiphilic, and can eliminate pathogenic microbes directly via electrostatic attraction toward negatively charged bacterial membranes. A number of studies have shown that LL-37 participates in various host immune systems, such as inflammatory responses and tissue repair, in addition to its antibacterial properties. Moreover, recent evidence suggests that it is also involved in the regulation of cancer. Indeed, previous studies have suggested that human LL-37 is involved in carcinogenesis via multiple reporters, such as FPR2 (FPRL1), epidermal growth factor receptor, and ERBb2, although LL-37 and its fragments and analogs also show anticancer effects in various cancer cell lines. This discrepancy can be attributed to peptide-based factors, host membrane-based factors, and signal regulation. Here, we describe the association between AMPs and cancer with a focus on anticancer peptide functions and selectivity in an effort to understand potential therapeutic implications.

Original languageEnglish
Article number144
JournalFrontiers in Oncology
Volume5
Issue numberJUN
DOIs
Publication statusPublished - 2015

Keywords

  • Anticancer
  • Antimicrobial peptides
  • Carcinogenesis
  • Cathelicidin
  • Ll-37

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'The human cathelicidin antimicrobial peptide LL-37 and mimics are potential anticancer drugs'. Together they form a unique fingerprint.

Cite this