The highly ordered assembly of retinal axons and their synaptic partners is regulated by Hedgehog/single-minded in the Drosophila visual system

Daiki Umetsu, Satoshi Murakami, Makoto Sato, Tetsuya Tabata

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

During development of the Drosophila visual center, photoreceptor cells extend their axons (R axons) to the lamina ganglion layer, and trigger proliferation and differentiation of synaptic partners (lamina neurons) by delivering the inductive signal Hedgehog (Hh). This inductive mechanism helps to establish an orderly arrangement of connections between the R axons and lamina neurons, termed a retinotopic map because it results in positioning the lamina neurons in close vicinity to the corresponding R axons. We found that the bHLH-PAS transcription factor Single-minded (Sim) is induced by Hh in the lamina neurons and is required for the association of lamina neurons with R axons. In sim mutant brains, lamina neurons undergo the first step of differentiation but fail to associate with R axons. As a result, lamina neurons are set aside from R axons. The data reveal a novel mechanism for regulation of the interaction between axons and neuronal cell bodies that establishes precise neuronal networks.

Original languageEnglish
Pages (from-to)791-800
Number of pages10
JournalDevelopment
Volume133
Issue number5
DOIs
Publication statusPublished - 2006 Mar
Externally publishedYes

Keywords

  • Drosophila
  • Hh
  • Lamina
  • Postsynaptic neuron
  • Sim
  • Visual system

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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