@article{a1c19ffecab34ba991a71595aee9615b,
title = "The gut microbiota induces Peyer's-patch-dependent secretion of maternal IgA into milk",
abstract = "The evolutionary strategy of transferring maternal antibodies via milk profoundly impacts the survival, lifelong health, and wellbeing of all neonates, including a pronounced impact on human breastfeeding success and infant development. While there has been increased recognition that interorgan connectivity influences the quality of a mother's milk, potentially to personalize it for her offspring, the underlying bases for these processes are incompletely resolved. Here, we define an essential role of Peyer's patches (PPs) for the generation of plasma cells that secrete maternal immunoglobulin A (IgA) into milk. Our metagenomic analysis reveals that the presence of certain residential microorganisms in the gastrointestinal (GI) tract, such as Bacteroides acidifaciens and Prevotella buccalis, is indispensable for the programming of maternal IgA synthesis prior to lactational transfer. Our data provide important insights into how the microbiome of the maternal GI environment, specifically through PPs, can be communicated to the next generation via milk.",
keywords = "Peyer's patches, mammary glands, maternal IgA, microbiome, milk",
author = "Katsuki Usami and Kanae Niimi and Ayumi Matsuo and Yoshihisa Suyama and Yoshifumi Sakai and Shintaro Sato and Kohtaro Fujihashi and Hiroshi Kiyono and Saeka Uchino and Mutsumi Furukawa and Jahidul Islam and Kaori Ito and Taiki Moriya and Yutaka Kusumoto and Michio Tomura and Hovey, {Russell C.} and Junichi Sugawara and Hiroshi Yoneyama and Haruki Kitazawa and Kouichi Watanabe and Hisashi Aso and Tomonori Nochi",
note = "Funding Information: We thank Drs. Mitsuru Matsumoto and Bao Lu for providing Ltbr−/− and Ccr10EGFP/EGFP mice, respectively; Mr. Yuki Arino and Ms. Nana Sato for their support at the animal facility of the Graduate School of Agricultural Science in Tohoku University; and Dr. Jumpei Sasabe for technical advice regarding IgA-seq analysis. This study was supported by Grants-in-Aid for Scientific Research (A; 18H03969 to T.N.), Grants-in-Aid for Challenging Research (Exploratory; 17K19882 to T.N. and 23659199 to S.S.), Grants-in-Aid for Young Scientists (A; 16H06207 to T.N.), and Core-to-Core Program (Advanced Research Networks) from the Japan Society for the Promotion of Science (to T.N. K.U. and R.C.H.); the Program for Interdisciplinary Research from the Frontier Research Institute for Interdisciplinary Sciences at Tohoku University (T.N.); Grant for Joint Research Project of the Institute of Medical Science, The University of Tokyo (to T.N.); Grant for Kibou Project of the Japanese Society for Immunology (to K.U.); and the research project on Regulatory Research Projects for Food Safety, Animal Health and Plant Protection from the Ministry of Agriculture, Forestry and Fisheries of Japan (T.N.). K.U. and T.N. designed the study. K.U. K.N. A.M. Y. Suyama, Y. Sakai, S.S. S.U. M.F. J.I. K.I. T.M. Y.K. M.T. and T.N. performed the research and analyzed the data. K.U. and T.N. wrote the paper, and all authors commented on it. K.F. H. Kiyono, R.C.H. J.S. H.Y. H. Kitazawa, K.W. and H.A. assisted in the writing and discussion. The authors declare no competing interests. Funding Information: We thank Drs. Mitsuru Matsumoto and Bao Lu for providing Ltbr −/− and Ccr10 EGFP/EGFP mice, respectively; Mr. Yuki Arino and Ms. Nana Sato for their support at the animal facility of the Graduate School of Agricultural Science in Tohoku University; and Dr. Jumpei Sasabe for technical advice regarding IgA-seq analysis. This study was supported by Grants-in-Aid for Scientific Research (A; 18H03969 to T.N.), Grants-in-Aid for Challenging Research (Exploratory; 17K19882 to T.N. and 23659199 to S.S.), Grants-in-Aid for Young Scientists (A; 16H06207 to T.N.), and Core-to-Core Program (Advanced Research Networks) from the Japan Society for the Promotion of Science (to T.N., K.U., and R.C.H.); the Program for Interdisciplinary Research from the Frontier Research Institute for Interdisciplinary Sciences at Tohoku University (T.N.); Grant for Joint Research Project of the Institute of Medical Science, The University of Tokyo (to T.N.); Grant for Kibou Project of the Japanese Society for Immunology (to K.U.); and the research project on Regulatory Research Projects for Food Safety, Animal Health and Plant Protection from the Ministry of Agriculture, Forestry and Fisheries of Japan (T.N.). Publisher Copyright: {\textcopyright} 2021 The Author(s)",
year = "2021",
month = sep,
day = "7",
doi = "10.1016/j.celrep.2021.109655",
language = "English",
volume = "36",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "10",
}
