The Functional Palliative Prognostic Index: a scoring system for functional prognostication of patients with advanced cancer

Yusuke Hiratsuka, Takuhiro Yamaguchi, Isseki Maeda, Tatsuya Morita, Masanori Mori, Naosuke Yokomichi, Shuji Hiramoto, Yosuke Matsuda, Hiroyuki Kohara, Kozue Suzuki, Keita Tagami, Takashi Yamaguchi, Akira Inoue

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: For appropriate advance care planning, functional prognostication is necessary. However, there are no studies of functional prognostication in patients with cancer. The aim of this study was to develop a functional prognostic scoring system for patients with advanced cancer. Methods: In this multicenter prospective observational study, 1896 patients were enrolled. First, Cox regression analysis and the combination of forward and backward variable selection were used to identify the best subset of predictors. Second, the prognostic score value was defined from each regression coefficient of a significant prognostic factor. The Functional Palliative Prognostic Index (FPPI) was calculated by summing the prognostic scores. Results: Patients were classified into three groups by the FPPI. For walking, the 14-day functional survival probability was > 72.8% for group A (score 0), 28.4–72.8% for group B (score 1), and < 28.4% for group C (score 2–3). For eating, the 14-day functional survival probability was > 71.8% for group A (score 0–3), 29.6–71.8% for group B (score 3.5–5.5), and < 29.6% for group C (score 6–9). For communicating, the 14-day functional survival probability was > 76.6% for group A (score 0–6.5), 22.6–76.6% for group B (score 7–10), and < 22.6% for group C (score 10.5–16). Regarding each item, group B functionally survived significantly longer than group C, and group A functionally survived significantly longer than either of the others. Conclusion: We firstly developed a functional prognostic scoring system for patients with advanced cancer. This FPPI system promises to be helpful in advance care planning.

Original languageEnglish
Pages (from-to)6067-6074
Number of pages8
JournalSupportive Care in Cancer
Volume28
Issue number12
DOIs
Publication statusPublished - 2020 Dec

Keywords

  • Advance care planning
  • Advanced cancer
  • Decision-making
  • Functional prognostication
  • Palliative care
  • Palliative care unit

ASJC Scopus subject areas

  • Oncology

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