The Function and Prognostic Significance of Cripto-1 in Colorectal Cancer

Jun Sato, Hideaki Karasawa, Takashi Suzuki, Shun Nakayama, Munetoshi Katagiri, Shimpei Maeda, Shinobu Ohnuma, Fuyuhiko Motoi, Takeshi Naitoh, Michiaki Unno

Research output: Contribution to journalArticlepeer-review

Abstract

Cripto-1 is a plasma membrane protein which is not expressed in adult tissue, but some tumors are accompanied by re-activation. We studied the clinical and biological significance of Cripto-1 in colorectal cancer. Cripto-1 was positive in 68 out of 192 cases (35%) by immunohistochemistry. Cripto-1 expression was correlated with worse prognosis and was an independent prognostic factor. Cripto-1-silenced colorectal cancer cell lines had reduced cell proliferation, migration, and activation of Akt and MAPK signaling pathways in vitro, and decreased tumor growth and lymph node metastasis in vivo. Cripto-1 could be a useful prognostic biomarker and therapeutic target in colorectal cancer.

Original languageEnglish
Pages (from-to)214-227
Number of pages14
JournalCancer Investigation
Volume38
Issue number4
DOIs
Publication statusPublished - 2020 Apr 20
Externally publishedYes

Keywords

  • Colorectal cancer
  • Cripto-1
  • immunohistochemistry
  • orthotopic xenograft model
  • prognostic marker

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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