The fruit of Acanthopanax senticosus (Rupr. et Maxim.) Harms improves insulin resistance and hepatic lipid accumulation by modulation of liver adenosine monophosphate–activated protein kinase activity and lipogenic gene expression in high-fat diet–fed obese mice

Tetsuo Saito, Miyako Nishida, Masafumi Saito, Akari Tanabe, Takahiro Eitsuka, Shi Hua Yuan, Nobuo Ikekawa, Hiroshi Nishida

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Obesity-associated insulin resistance is a major risk factor for most metabolic diseases, including dyslipidemia and type 2 diabetes. Acanthopanax senticosus (Rupr. et Maxim.) Harms (Goka) root has been used in traditional Chinese medicine for treatment of diabetes and other conditions; however, little is known about the effects of Goka fruit (GF). Goka fruit is rich in anthocyanin, which has beneficial effects on obesity and insulin resistance via activation of adenosine monophosphate–activated protein kinase (AMPK). We hypothesized that GF can improve obesity-associated insulin resistance. The aim of the present study was to investigate whether GF improves insulin resistance in high-fat diet (HFD)–induced obese mice. High-fat diet mice treated with GF (500 and 1000 mg/kg) for 12 weeks showed an improved glucose tolerance and insulin sensitivity, as well as reduced plasma insulin and liver lipid accumulation. Moreover, GF administration to HFD mice resulted in down-regulation of fatty acid synthase expression and up-regulation of cholesterol 7-alpha-hydroxylase expression in the liver. Notably, AMPK phosphorylation in the liver increased after GF administration. In summary, GF supplementation improved obesity-associated insulin resistance and hepatic lipid accumulation through modulation of AMPK activity and lipid metabolism–associated gene expression.

Original languageEnglish
Pages (from-to)1090-1097
Number of pages8
JournalNutrition Research
Volume36
Issue number10
DOIs
Publication statusPublished - 2016 Oct 1
Externally publishedYes

Keywords

  • AMP-activated protein kinase
  • Acanthopanax senticosus (Rupr. et Maxim.) Harms
  • Glucose intolerance
  • High-fat diet
  • Insulin resistance

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

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