TY - GEN
T1 - The formation of the embryonic mouse heart
T2 - Heart fields and myocardial cell lineages: Annals of the new york academy of sciences
AU - Watanabe, Yusuke
AU - Buckingham, Margaret
PY - 2010/1/1
Y1 - 2010/1/1
N2 - During cardiogenesis in the mouse, the second heart field (SHF) is the source of the myocardium of the outflow tract and it contributes to other regions of the heart with the exception of the primitive left ventricle. This contribution corresponds with that of the second myocardial cell lineage, identified by retrospective clonal analysis. Gene regulatory networks, signaling pathways, and heterogeneity within the SHF are discussed, together with the question of regulation of myocardial progenitor cells within the first heart field. The extension of the SHF into the mesodermal core of the arches also gives rise to endothelial cells of the pharyngeal arch arteries. Knowledge about the origin and genetic regulation of cells that contribute to the heart and associated vasculature is important for the diagnosis and treatment of congenital heart malformations.
AB - During cardiogenesis in the mouse, the second heart field (SHF) is the source of the myocardium of the outflow tract and it contributes to other regions of the heart with the exception of the primitive left ventricle. This contribution corresponds with that of the second myocardial cell lineage, identified by retrospective clonal analysis. Gene regulatory networks, signaling pathways, and heterogeneity within the SHF are discussed, together with the question of regulation of myocardial progenitor cells within the first heart field. The extension of the SHF into the mesodermal core of the arches also gives rise to endothelial cells of the pharyngeal arch arteries. Knowledge about the origin and genetic regulation of cells that contribute to the heart and associated vasculature is important for the diagnosis and treatment of congenital heart malformations.
KW - Cardiogenesis
KW - Mouse embryos
KW - Myocardial cell lineages
KW - Second heart field
UR - http://www.scopus.com/inward/record.url?scp=77649119509&partnerID=8YFLogxK
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U2 - 10.1111/j.1749-6632.2009.05078.x
DO - 10.1111/j.1749-6632.2009.05078.x
M3 - Conference contribution
C2 - 20201881
AN - SCOPUS:77649119509
SN - 9781573317474
T3 - Annals of the New York Academy of Sciences
SP - 15
EP - 24
BT - Analysis of Cardiac Development
PB - Blackwell Publishing Inc.
ER -