The formation of the embryonic mouse heart: Heart fields and myocardial cell lineages: Annals of the new york academy of sciences

Yusuke Watanabe, Margaret Buckingham

Research output: Chapter in Book/Report/Conference proceedingConference contribution

15 Citations (Scopus)

Abstract

During cardiogenesis in the mouse, the second heart field (SHF) is the source of the myocardium of the outflow tract and it contributes to other regions of the heart with the exception of the primitive left ventricle. This contribution corresponds with that of the second myocardial cell lineage, identified by retrospective clonal analysis. Gene regulatory networks, signaling pathways, and heterogeneity within the SHF are discussed, together with the question of regulation of myocardial progenitor cells within the first heart field. The extension of the SHF into the mesodermal core of the arches also gives rise to endothelial cells of the pharyngeal arch arteries. Knowledge about the origin and genetic regulation of cells that contribute to the heart and associated vasculature is important for the diagnosis and treatment of congenital heart malformations.

Original languageEnglish
Title of host publicationAnalysis of Cardiac Development
Subtitle of host publicationFrom Embryo to Old Age
PublisherBlackwell Publishing Inc.
Pages15-24
Number of pages10
ISBN (Print)9781573317474
DOIs
Publication statusPublished - 2010 Jan 1

Publication series

NameAnnals of the New York Academy of Sciences
Volume1188
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Cardiogenesis
  • Mouse embryos
  • Myocardial cell lineages
  • Second heart field

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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