The first synthesis of chiral phosphinocarboxylic acid ligands, trans-2-(diphenylphosphino)cycloalkanecarboxylic acids. The phosphine-palladium complexes catalyzed asymmetric allylic alkylation

Yoshiharu Okada, Toru Minami, Yoritaka Sasaki, Yasuo Umezu, Masahiko Yamaguchi

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

The first synthesized chiral phosphinocarboxylic acids were effective as ligand for the palledium-catalyzed asymmetric allylic alkylation of 3-acetoxy-1,3-diphenyl-1-propene and 2-cyclohexenyl acetate with soft carbanion from dimethyl malonate or triethyl phosphonoacetate and sodium hydride to give the alkylation products of up to 83% ee.

Original languageEnglish
Pages (from-to)3905-3908
Number of pages4
JournalTetrahedron Letters
Volume31
Issue number27
DOIs
Publication statusPublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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