The first infant case with hepatosplenic γδ T-cell lymphoma after acute disseminated encephalomyelitis (ADEM)-like exacerbation

Shinichiro Y. Koga, Satoru Kumaki, Ryo Ichinohasama, Mitsutoshi Munakata, Kazuhiro Haginoya, Yoshiyuki Ohashi, Yoshiko Tanaka, Osamu Sakamoto, Masayoshi Minegishi, Tomohiro Morio, Kazuie Iinuma, Shigeru Tsuchiya

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

We report the first infant case with hepatosplenic γδ T-cell lymphoma after recurrent acute disseminated encephalomyelitis-like, which were rapidly resolved with steroid pulse therapy. The patient had a history of recurrent bronchitis, intractable diarrhea, and failure to thrive since 4 months of age. Immunologic analysis revealed higher percentage of circulating γδ T-cells with markedly reduced numbers of CD3TCRαβCD8 T-cells. The patient developed γδ T-cell lymphoma at the age of 15 months. Clinical course of the patient suggests the importance of immunological background for the development of hepatosplenic γδ T-cell lymphoma.

Original languageEnglish
Pages (from-to)741-745
Number of pages5
JournalJournal of Pediatric Hematology/Oncology
Volume28
Issue number11
DOIs
Publication statusPublished - 2006 Nov

Keywords

  • Acute disseminated encephalomyelitis
  • CD3TCRαβ CD8 T-cell
  • Hepatosplenic γδ T-cell lymphoma
  • Infant
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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