TY - JOUR
T1 - The fickle mutation of a cytoplasmic tyrosine kinase effects sensitization but not dishabituation in Drosophila melanogaster
AU - Asztalos, Zoltan
AU - Baba, Kotaro
AU - Yamamoto, Daisuke
AU - Tully, Tim
N1 - Funding Information:
Received 10 January 2007; accepted 21 January 2007. This work was supported by NIH grant MH066242 and Dart Neuroscience Inc. *Zottan Asztalos’s current address is: Aktogen Ltd., Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK. Address correspondence to Tim Tully, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724 USA. E-mail: tully@cshl.edu
PY - 2007/1
Y1 - 2007/1
N2 - fickle is a P-element mutation identified from a screen for defects in courtship behavior and disrupts the fly homolog of Bruton's tyrosine kinase (Btk) gene (Baba et al., 1999). Here, we show that habituation of the olfactory jump reflex also is defective in fickle. Unlike, the prototypical memory mutants, rutabaga and dunce, which habituate more slowly than normal, fickle flies habituate faster than normal. fickle's faster-than-normal response decrement did not appear to be due to sensorimotor fatigue, and dishabituation of the jump response was normal. Based on a long-standing "two opponent process" theory of habituation, these data suggested that behavioral sensitization might be defective in fickle. To test this hypothesis, we designed a olfactory sensitization procedure, using the same stimuli to habituate (odor) and dishabituate (vortexing) flies. Mutant flies failed to show any sensitization with this procedure. Our study reveals a "genetic dissection" of sensitization and dishabituation and, for the first time, provides a biological confirmation of the two opponent process theory of habituation.
AB - fickle is a P-element mutation identified from a screen for defects in courtship behavior and disrupts the fly homolog of Bruton's tyrosine kinase (Btk) gene (Baba et al., 1999). Here, we show that habituation of the olfactory jump reflex also is defective in fickle. Unlike, the prototypical memory mutants, rutabaga and dunce, which habituate more slowly than normal, fickle flies habituate faster than normal. fickle's faster-than-normal response decrement did not appear to be due to sensorimotor fatigue, and dishabituation of the jump response was normal. Based on a long-standing "two opponent process" theory of habituation, these data suggested that behavioral sensitization might be defective in fickle. To test this hypothesis, we designed a olfactory sensitization procedure, using the same stimuli to habituate (odor) and dishabituate (vortexing) flies. Mutant flies failed to show any sensitization with this procedure. Our study reveals a "genetic dissection" of sensitization and dishabituation and, for the first time, provides a biological confirmation of the two opponent process theory of habituation.
KW - Behavioral
KW - Drosophila
KW - Enzymatic mutant
KW - Olfactory jump reflex
KW - Sensitization
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U2 - 10.1080/01677060701249488
DO - 10.1080/01677060701249488
M3 - Article
C2 - 17464798
AN - SCOPUS:34247554226
VL - 21
SP - 59
EP - 71
JO - Journal of Neurogenetics
JF - Journal of Neurogenetics
SN - 0167-7063
IS - 1-2
ER -