The Feature of the Interstitial Nano Drug Delivery System with Fluorescent Nanocrystals of Different Sizes in the Human Tumor Xenograft in Mice

M. Kawai, M. Takeda, N. Ohuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Recent anticancer drugs are made to be larger to selectively pass the tumor vessel and to stay in the interstitium. Understanding of the drug movement in a single molecule is indispensable to optimize drug delivery. Here we report the tracking of single nano-particles with different sizes in tumor xenografts in vivo. The motions of the nano-crystals were clearly observed and random with one-way movement. The analysis of the trajectory shows that contribution of diffusion and interstitial fluid current to the delivery processes. The diffusion coefficient was inversely related to the size and position and velocity was related to the position of the particles. Our data are basic and important for understanding pharmacokinetics and convenient finding for constructing novel drug delivery system.

Original languageEnglish
Title of host publication13th International Conference on Biomedical Engineering - ICBME 2008
Pages2241-2243
Number of pages3
DOIs
Publication statusPublished - 2009
Event13th International Conference on Biomedical Engineering, ICBME 2008 - , Singapore
Duration: 2008 Dec 32008 Dec 6

Publication series

NameIFMBE Proceedings
Volume23
ISSN (Print)1680-0737

Other

Other13th International Conference on Biomedical Engineering, ICBME 2008
Country/TerritorySingapore
Period08/12/308/12/6

Keywords

  • Drug Delivery System
  • Nanomedicine

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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