The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis

Takeshi Inagaki, Satoshi Iwasaki, Yoshihiro Matsumura, Takeshi Kawamura, Toshiya Tanaka, Yohei Abe, Ayumu Yamasaki, Yuya Tsurutani, Ayano Yoshida, Yoko Chikaoka, Kanako Nakamura, Kenta Magoori, Ryo Nakaki, Timothy F. Osborne, Kiyoko Fukami, Hiroyuki Aburatani, Tatsuhiko Kodama, Juro Sakai

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Background: Polycomb repressive complex PRC1 is an epigenetic regulator of cellular differentiation. However, its function during adipogenesis is unknown. Results: FBXL10/KDM2B recruited noncanonical PRC1 complex in F-box and LRR motifs dependent on cell cycle-related genes and Pparg genes and repressed 3T3-L1 adipogenesis. Conclusion: Noncanonical PRC1 complex containing FBXL10/KDM2B regulates adipogenesis. Significance: Our findings revealed a novel epigenetic mechanism of adipogenesis.

Original languageEnglish
Pages (from-to)4163-4177
Number of pages15
JournalJournal of Biological Chemistry
Volume290
Issue number7
DOIs
Publication statusPublished - 2015 Feb 13
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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