The expression of S100A4 in human pancreatic cancer is associated with invasion

Nobukazu Tsukamoto, Shinichi Egawa, Masanori Akada, Keiko Abe, Yuriko Saiki, Naoyuki Kaneko, Satoru Yokoyama, Kentaro Shima, Akihiro Yamamura, Fuyuhiko Motoi, Hisashi Abe, Hiroki Hayashi, Kazuyuki Ishida, Takuya Moriya, Takahiro Tabata, Emiko Kondo, Naomi Kanai, Zhaodi Gu, Makoto Sunamura, Michiaki UnnoAkira Horii

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

OBJECTIVES: Pancreatic cancer is one of the most lethal malignancies; its poor prognosis is strongly associated with invasion and metastasis. Expression of S100A4 has been reported to correlate with poor prognosis in various cancers. We have investigated the role of S100A4 in pancreatic cancer tumorigenesis and its clinicopathologic significance. METHODS: Protein expression of S100A4 was examined by Western blot in pancreatic cancer cell lines and a human pancreatic ductal epithelium cell line, HPDE-6. Then the expressions of S100A4, TP53, and CD133 were examined immunohistochemically in resected specimens from 83 patients with pancreatic cancer to clarify their clinicopathologic significance. Survival analyses were performed using the Kaplan-Meier method and the Mantel-Cox method. RESULTS: Forty-eight (58%) of 83 patients with pancreatic cancer positively expressed S100A4, and 50 (60%) and 29 (36%) patients positively expressed TP53 and CD133, respectively. S100A4 expression was significantly correlated with perineural invasion (P = 0.029) and invasion pattern (P = 0.001). Neither TP53 nor CD133 expression showed significant correlations with any other parameters. CONCLUSIONS: Our present results suggest that S100A4 plays an important role in the invasiveness, particularly with perineural invasion and invasion pattern, of pancreatic cancer. Development of new strategies targeting S100A4 or its downstream effectors is warranted.

Original languageEnglish
Pages (from-to)1027-1033
Number of pages7
JournalPancreas
Volume42
Issue number6
DOIs
Publication statusPublished - 2013 Aug

Keywords

  • S100A4
  • TP53
  • clinicopathologic significance
  • immunohistochemistry
  • pancreatic cancer
  • tissue microarray

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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