The expression of presenilin 1 mRNA in skin fibroblasts and brains from sporadic Alzheimer's disease

Kazuyuki Ikeda, Katsuya Urakami, Hiroyuki Arai, Kenji Wada, Yosuke Wakutani, Yong Ji, Yoshiki Adachi, Akitsugu Okada, Hisanori Kowa, Hidetada Sasaki, Kousaku Ohno, Yuzuru Ohtsuka, Yukihiro Ishikawa, Kenji Nakashima

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

We examined the expression of presenilin 1 (PS-1) mRNA in cultured skin fibroblasts taken from living patients with Alzheimer's disease (AD) and human brains taken postmortem from AD patients by RT-PCR analysis. The donors of fibroblasts consisted of 28 cases with AD and 19 neurological patient without dementia (CTL). The brains came from 17 cases with AD and 23 cases with CTL. We found that PS-1 mRNA levels in skin fibroblasts of AD patients were significantly higher than those of CTL patients (p < 0.0001). Moreover, we found that PS-1 mRNA levels in human brains with AD were significantly higher than in those with CTL (p < 0.0001). These findings suggest that high levels of PS-1 mRNA in AD may play an important role in developing AD and that the examination of PS-1 mRNA in skin fibroblasts may be helpful for the diagnosis of AD. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)245-250
Number of pages6
JournalDementia and geriatric cognitive disorders
Volume11
Issue number5
DOIs
Publication statusPublished - 2000

Keywords

  • Human brains
  • Presenilin 1
  • Skin fibroblasts
  • Sporadic Alzheimer's disease
  • mRNA

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

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