The expression of Fn14 via mechanical stress-activated JNK contributes to apoptosis induction in osteoblasts

Hiroyuki Matsui, Naoto Fukuno, Yoshiaki Kanda, Yusuke Kantoh, Toko Chida, Yuko Nagaura, Osamu Suzuki, Hideki Nishitoh, Kohsuke Takeda, Hidenori Ichijo, Yasuhiro Sawada, Keiichi Sasaki, Takayasu Kobayashi, Shinri Tamura

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28 Citations (Scopus)

Abstract

Background: Fn14 is a highly inducible member of the TNF receptor family. Results: Large-magnitude mechanical stress induced Fn14 expression via JNK in osteoblasts. Conclusion: Expression of Fn14 regulates mechanical stress-induced apoptosis in osteoblasts. Significance: This is the first elucidation of the mechanism of excessive mechanical stress-induced apoptosis mediated by Fn14.

Original languageEnglish
Pages (from-to)6438-6450
Number of pages13
JournalJournal of Biological Chemistry
Volume289
Issue number10
DOIs
Publication statusPublished - 2014 Mar 7

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Matsui, H., Fukuno, N., Kanda, Y., Kantoh, Y., Chida, T., Nagaura, Y., Suzuki, O., Nishitoh, H., Takeda, K., Ichijo, H., Sawada, Y., Sasaki, K., Kobayashi, T., & Tamura, S. (2014). The expression of Fn14 via mechanical stress-activated JNK contributes to apoptosis induction in osteoblasts. Journal of Biological Chemistry, 289(10), 6438-6450. https://doi.org/10.1074/jbc.M113.536300