The enhancement of th1 immune response by anti-pd-l1 antibody in cattle infected with mycobacterium avium subsp. Paratuberculosis

Yamato Sajiki, Satoru Konnai, Reiko Nagata, Satoko Kawaji, Hayato Nakamura, Sotaro Fujisawa, Tomohiro Okagawa, Naoya Maekawa, Yukinari Kato, Yasuhiko Suzuki, Shiro Murata, Yasuyuki Mori, Kazuhiko Ohashi

Research output: Contribution to journalComment/debatepeer-review

Abstract

Johne’s disease, caused by Mycobacterium avium subsp. paratuberculosis (MAP), is a chronic enteritis of ruminants. Previous studies have shown that programmed death-ligand 1 (PD-L1) is associated with the disease progression, and PD-L1 blockade activates MAP-specific Th1 responses in vitro. Here, we performed anti-PD-L1 antibody administration using 2 MAP-infected cattle at the late subclinical stage of infection. After administration, bacterial shedding was reduced or maintained at a low level. Additionally, MAP-specific Th1 cytokine production was upregulated, and CD69 expression was increased in T cells. Collectively, the treatment has a potential as a novel control method against Johne’s disease.

Original languageEnglish
Pages (from-to)162-166
Number of pages5
JournalJournal of Veterinary Medical Science
Volume83
Issue number2
DOIs
Publication statusPublished - 2021

Keywords

  • Cattle
  • Immunotherapy
  • Johne’s disease
  • Programmed death-ligand 1
  • Th1 response

ASJC Scopus subject areas

  • veterinary(all)

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