The electrochemistry and determination of Ligustrazine hydrochloride

Ziyi Sun, Xiaofeng Zheng, Tomonori Hoshi, Yoshitomo Kashiwagi, Jun Ichi Anzai, Genxi Li

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Ligustrazine is one of the active ingredients contained in Ligusticum chuanxiong Hort. (Umbelliferae), which is widely used in traditional Chinese medicine for the treatment of cardiovascular problems. In this work, the electrochemistry of Ligustrazine hydrochloride (LZC) and its determination are investigated. The detection limit is estimated to be 8.0×10-8 M, with three linear ranges from 1.0×10-6 to 1.0×10 -4 M, 1.0×10-4 to 5.0×10-4 M, and 6.5×10-4 to 1.0×10-3 M. The method has been proved to be highly sensitive, selective, and stable, and has been successfully applied to determining LZC in LZC injections.

Original languageEnglish
Pages (from-to)545-550
Number of pages6
JournalAnalytical and Bioanalytical Chemistry
Volume380
Issue number3 SPEC.ISS.
DOIs
Publication statusPublished - 2004 Oct

Keywords

  • Cyclic voltammetry
  • Determination
  • Ligustrazine hydrochloride
  • Pyrolytic graphite
  • Square wave voltammetry

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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