The effects of prostaglandin f on vascular permeability and collagen and non-collagen protein synthesis of preformed chronic carrageenin granuloma in rats

Kazuo Ohuchi, Hiroshi Sato, Susumu Tsurufuji

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Prostaglandin F (PG F) was administered into the pouch fluid of 7-day-old carrageenin granuloma in rats and the effects of PG F on vascular permeability and collagen and non-collagen protein synthesis of the granuloma were investigated. At a dose of 10 μg of PG F, vascular permeability as measured by the leakage of radioiodinated human serum albumin into the pouch fluid was not inhibited, but at doses of 50, 100 and 250 μg of PG F, vascular permeability was inhibited significantly. The incorporation of [3H]proline into collagen hydroxyproline and into non-collagen protein of carrageenin granuloma was also inhibited by local administration of PG F. The mechanism of the effects of PG F is discussed.

Original languageEnglish
Pages (from-to)2049-2053
Number of pages5
JournalBiochemical Pharmacology
Volume26
Issue number21
DOIs
Publication statusPublished - 1977 Nov 1

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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