Prostaglandin F2α (PG F2α) was administered into the pouch fluid of 7-day-old carrageenin granuloma in rats and the effects of PG F2α on vascular permeability and collagen and non-collagen protein synthesis of the granuloma were investigated. At a dose of 10 μg of PG F2α, vascular permeability as measured by the leakage of radioiodinated human serum albumin into the pouch fluid was not inhibited, but at doses of 50, 100 and 250 μg of PG F2α, vascular permeability was inhibited significantly. The incorporation of [3H]proline into collagen hydroxyproline and into non-collagen protein of carrageenin granuloma was also inhibited by local administration of PG F2α. The mechanism of the effects of PG F2α is discussed.
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