Silver is a broad-spectrum antimicrobial agent that controls bacteria, yeast and viruses. It kills microbes through multiple mechanisms of action, such as inhibiting cellular respiration, denaturing nucleic acids and cellular membrane permeability. Silver has low mammalian cell toxicity. Silver nitrate and silver sulfadiazine were the primary source of silver, however, new silver-containing modern dressings have been marketed for use on chronic wounds. They are designed to maintain a moist environment with sustained release of silver over several days. To date, there are four published randomized controlled trials in the treatment of chronic wounds. Positive effects were found for outcome assessments, however, the methodological flaws of these studies impede drawing causal inferences.
|Number of pages||6|
|Journal||Japanese Journal of Plastic Surgery|
|Publication status||Published - 2009 Aug|
- Critical colonization
- Oligodynamic effect
ASJC Scopus subject areas