The effects of dressings and ointments containing silver

Masahiro Tachi, Sohachi Toriyabe

Research output: Contribution to journalArticlepeer-review


Silver is a broad-spectrum antimicrobial agent that controls bacteria, yeast and viruses. It kills microbes through multiple mechanisms of action, such as inhibiting cellular respiration, denaturing nucleic acids and cellular membrane permeability. Silver has low mammalian cell toxicity. Silver nitrate and silver sulfadiazine were the primary source of silver, however, new silver-containing modern dressings have been marketed for use on chronic wounds. They are designed to maintain a moist environment with sustained release of silver over several days. To date, there are four published randomized controlled trials in the treatment of chronic wounds. Positive effects were found for outcome assessments, however, the methodological flaws of these studies impede drawing causal inferences.

Original languageEnglish
Pages (from-to)913-918
Number of pages6
JournalJapanese Journal of Plastic Surgery
Issue number8
Publication statusPublished - 2009 Aug


  • Critical colonization
  • Oligodynamic effect

ASJC Scopus subject areas

  • Surgery


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