The effects of cortisol on heat shock protein 70 levels in two fish species

N. Basu, T. Nakano, E. G. Grau, G. K. Iwama

Research output: Contribution to journalArticlepeer-review

132 Citations (Scopus)

Abstract

We studied the relationship between heat stress (2 h, +12°) and increased levels of circulating Cortisol (50 μg cortisol/g body weight) on heat shock protein 70 (hsp70) levels in liver and gill tissues of rainbow trout (Oncorhynchus mykiss) and tilapia (Oreochromis mossambicus). The administration of Cortisol by intraperitoneal injection (no heat stress) did not alter tissue hsp70 levels compared to sham implanted (no heat stress) trout and tilapia. We found elevated levels of cortisol significantly suppressed the heat stress-induced levels of hepatic hsp70 by 34.2% and 31.0%, 3 and 24 h post-heat stress, respectively, compared to sham implanted trout. Additionally, elevated levels of cortisol significantly suppressed the heat stress-induced levels of gill hsp70 by 66.2% in trout (3 h post stress) and 26.7% in tilapia (4 h post stress), compared to sham implanted fish. These results suggest that cortisol may be mediating hsp70 levels in fish tissues following times of physiological stress, and that the neuroendocrine and cellular stress responses may be functionally related in these two different species of fish.

Original languageEnglish
Pages (from-to)97-105
Number of pages9
JournalGeneral and Comparative Endocrinology
Volume124
Issue number1
DOIs
Publication statusPublished - 2001

Keywords

  • Cortisol
  • Fish
  • Stress response
  • hsp70

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Endocrinology

Fingerprint

Dive into the research topics of 'The effects of cortisol on heat shock protein 70 levels in two fish species'. Together they form a unique fingerprint.

Cite this