The effects of cigarette smoke condensate and nicotine on periodontal tissue in a periodontitis model mouse

Mikiko Kubota, Manabu Yanagita, Kenta Mori, Shiori Hasegawa, Motozo Yamashita, Satoru Yamada, Masahiro Kitamura, Shinya Murakami

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Cigarette smoking is a major lifestyle-related risk factor for periodontal diseases. However, the pathophysiological role of cigarette smoking in periodontal disease has yet to be fully elucidated. Here we report that the systemic administration of cigarette smoke condensate or nicotine, which is the major ingredient of cigarette smoke, augmented alveolar bone loss. Concomitantly, the number of osteoclasts in periodontal tissues increased and the expression of receptor activator of nuclear factor κB ligand was upregulated at the ligated side in mice with periodontitis. Nicotine also attenuated alveolar bone repair after ligature removal. These observations highlight the destruction of periodontal tissue by smoking and the unfavorable clinical course of periodontal disease in patients with a cigarette smoking habit. The present study demonstrates that periodontal disease models are useful for elucidating the pathogenesis of cigarette smoking-related periodontal diseases.

Original languageEnglish
Article numbere0155594
JournalPloS one
Volume11
Issue number5
DOIs
Publication statusPublished - 2016 May 1
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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