TY - JOUR
T1 - The Effects of Atrial Natriuretic Peptide on Renal Function and the Renin-Aldosterone System in Anesthetized Rabbits
AU - Nushiro, Noboru
AU - Abe, Keishi
AU - Seino, Masahide
AU - Itoh, Sadayoshi
AU - Yoshinaga, Kaoru
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1987
Y1 - 1987
N2 - The Effects of Atrial Natriuretic Peptide on Renal Function and the Renin-Aldosterone System in Anesthetized Rabbits. Tohoku J. exp. Med., 1987, 152 (3), 301-310-To determine the effects of a-human atrial natriuretic peptide (ANP) on renal function and the renin-aldosterone system in anesthetized rabbits, ANP (0.05 µg/kg/min) or 5% dextrose solution in vehicle control was infused intravenously. The infusion of ANP resulted in a significant decrease in mean arterial pressure with an increase in renal blood flow (RBF). ANP also produced significant increases in urine volume and urinary sodium excretion. ANP tended to increase glomerular filtration rate, filtered sodium load and net tubular reabsorption of sodium. However, there were no significant differences in these parameters compared with control group. Fractional sodium excretion was increased significantly by ANP. Plasma renin activity (PRA) was suppressed only at 30 min after the infusion of ANP, while a significant fall in plasma aldosterone concentration (PAC) lasted even in the recovery period. These results indicate that ANP produces a diuresis and natriuresis through the increased RBF in anesthetized rabbits. It is also suggested that ANP suppresses PAC independent of the inhibition of PRA.
AB - The Effects of Atrial Natriuretic Peptide on Renal Function and the Renin-Aldosterone System in Anesthetized Rabbits. Tohoku J. exp. Med., 1987, 152 (3), 301-310-To determine the effects of a-human atrial natriuretic peptide (ANP) on renal function and the renin-aldosterone system in anesthetized rabbits, ANP (0.05 µg/kg/min) or 5% dextrose solution in vehicle control was infused intravenously. The infusion of ANP resulted in a significant decrease in mean arterial pressure with an increase in renal blood flow (RBF). ANP also produced significant increases in urine volume and urinary sodium excretion. ANP tended to increase glomerular filtration rate, filtered sodium load and net tubular reabsorption of sodium. However, there were no significant differences in these parameters compared with control group. Fractional sodium excretion was increased significantly by ANP. Plasma renin activity (PRA) was suppressed only at 30 min after the infusion of ANP, while a significant fall in plasma aldosterone concentration (PAC) lasted even in the recovery period. These results indicate that ANP produces a diuresis and natriuresis through the increased RBF in anesthetized rabbits. It is also suggested that ANP suppresses PAC independent of the inhibition of PRA.
KW - atrial natriuretic peptide
KW - natriuresis
KW - renal hemodynamics
KW - renin-angiotensin-aldosterone system
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U2 - 10.1620/tjem.152.301
DO - 10.1620/tjem.152.301
M3 - Article
C2 - 2958960
AN - SCOPUS:0023265211
VL - 152
SP - 301
EP - 310
JO - Tohoku Journal of Experimental Medicine
JF - Tohoku Journal of Experimental Medicine
SN - 0040-8727
IS - 3
ER -