TY - JOUR
T1 - The effects of aging and Alzheimer's disease on associative recognition memory
AU - Hanaki, Risa
AU - Abe, Nobuhito
AU - Fujii, Toshikatsu
AU - Ueno, Aya
AU - Nishio, Yoshiyuki
AU - Hiraoka, Kotaro
AU - Shimomura, Tatsuo
AU - Iizuka, Osamu
AU - Shinohara, Mayumi
AU - Hirayama, Kazumi
AU - Mori, Etsuro
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2011/12
Y1 - 2011/12
N2 - We investigated the effects of aging and Alzheimer's disease (AD) on item and associative recognition memory. Three groups of participants (younger adults, elderly adults, and AD patients) studied photographs of common objects that were located on either the left or the right side of a black computer screen inside either a red or a blue square. In a subsequent old/new recognition memory test, the participants were presented with four kinds of stimuli: "intact" stimuli, which were presented as they were during the study phase; "location-altered" stimuli, which were presented in a different location; "coloraltered" stimuli, which were presented with a different surrounding color; and "new" stimuli, which consisted of photographs that had not been presented during the study phase. Compared with younger adults, the older adults showed equivalent performance in simple item recognition but worse performance in discriminating location-altered and color-altered stimuli. Compared with older adults, the AD patients showed equivalent performance in discriminating color-altered stimuli but worse performance in simple item recognition and the discrimination of locationaltered stimuli. We speculate that distinct structural and functional changes in specific brain regions that are caused by aging and AD are responsible for the different patterns of memory impairment.
AB - We investigated the effects of aging and Alzheimer's disease (AD) on item and associative recognition memory. Three groups of participants (younger adults, elderly adults, and AD patients) studied photographs of common objects that were located on either the left or the right side of a black computer screen inside either a red or a blue square. In a subsequent old/new recognition memory test, the participants were presented with four kinds of stimuli: "intact" stimuli, which were presented as they were during the study phase; "location-altered" stimuli, which were presented in a different location; "coloraltered" stimuli, which were presented with a different surrounding color; and "new" stimuli, which consisted of photographs that had not been presented during the study phase. Compared with younger adults, the older adults showed equivalent performance in simple item recognition but worse performance in discriminating location-altered and color-altered stimuli. Compared with older adults, the AD patients showed equivalent performance in discriminating color-altered stimuli but worse performance in simple item recognition and the discrimination of locationaltered stimuli. We speculate that distinct structural and functional changes in specific brain regions that are caused by aging and AD are responsible for the different patterns of memory impairment.
KW - Aging
KW - Alzheimer's disease
KW - Associative recognition
KW - Item recognition
KW - Memory
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U2 - 10.1007/s10072-011-0748-4
DO - 10.1007/s10072-011-0748-4
M3 - Article
C2 - 21904867
AN - SCOPUS:84856230287
VL - 32
SP - 1115
EP - 1122
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 6
ER -